Vernon 2007 will be the closest thing to Vlad. Just pure suckage. They are also comparable in terms of talent and star level - their WAR highs and lows are similar.
Hinske 2003 was hugely disappointing
Bo's 2024 is right there
Alex Rios in 2009 lmao
You almost want to compare it to the big pitcher losses for injuries, like Johnson, Halladay, Stroman, BJ Ryan, but those you can just write off in a few days and you don't get mad at the player because it's not their fault. It's that magnitude of sudden loss but you hate the player so much more for it.
I am sure there were a bunch of huge disappointments on the 1994 and 1995 Blue Jays but I don't know. Fans were not as savvy. They probably still likes Joe Carter because .250 with 25 homers was still "solid production."