Just my opinion, putting on my manager's hat, but I rest absolutely everyone who can be rested on Tuesday. I'm talking a disgusting starting OF of Tapia, Zimmer, Bradley. Moreno at C. DH whoever is in a funk. Let all the regulars start for a couple of AB on Wednesday so that they keep their game timing with the off day. Substitute like crazy in the later innings.
For relievers, I would pitch all of the high leverage guys for one inning on Tuesday only in case they need to be abused for the WC series (e.g., Romano three days in a row). They should be throwing darts in Game 1.
For Wednesday, I would option Pop and White and piece together 9 innings using Kikuchi, Lawrence, Merryweather, and possibly Richards/Phelps.
Hot take, but I want Manoah pitching like 1 inning on Wednesday. Extra rest is good for a power pitcher, but multiple extra days can add rust.