Yeah... and Ray and Berrios were available for 8 months combined, next year it will be 6. So in one sense Berrios has replaced Ray already, and now (if trying to replicate the 2021 team) you need to replace 2 months of Berrios with another deadline deal... of course they'll do more than that and try to get another top rotation piece for the full year for 2022, and if they do team will look good going in.
[edit] yes injuries, health, once in a lifetime all star and cy young seasons, blah, blah, blah... but we are talking Ray and Semien leaving, not injury luck.