They need to run studies on the physics of different pitches and how they are affected by the altitude. I've read an article where fastballs and sliders are least affected so if true it would probably be a smart idea to get pitchers who can rely on throwing a lot of fastballs and sliders, Jon Gray being a good start. Whatever other studies they could do, they should be done as well. Perhaps good defensive players are extra important with a heightened run atmosphere like that, for example. They should constantly be searching for whatever edge they can get in that ballpark.
But ownership isn't interested in running a team like that. They've basically had the same type of old-school GM for decades and it's not a very forward thinking front office. They view the ballpark as a curse but it doesn't have to be. If they maximized whatever benefits and/or mitigated whatever detriments Coors Field offers they could be playing to an advantage 81 times a season. Instead they field broken teams that don't properly take advantage of the quirky home park.