I guess when it's a 0-0 game and your offense looks like chicken s***, this is what game day conversation must resort to.
It would have to be male to female, because a natural female has no chance, but it has to be a male to female who has actually done nothing hormonally to be a female and is still completely male and is just a dude who calls himself Cindy. And this will be celebrated as something revolutionary and they will put him...her in the Hall of Fame for it.
That's my guess.