I do too, because there are a few variables at play that I mentioned earlier too that are hard to quantify, but generally follow suit:
You're more likely to use your better relievers with the lead
The other team is more likely to use their lower leverage guys when trailing
If applicable, your better defenders enter the game
Less pressure on your own D, more pressure on the other team to produce
I'll leave it to the sabr nerds to answer, but its an interesting topic nonetheless.