Cueto did a pretty good job suppressing hard contact and missing barrels despite the complete lack of whiffs. His expected home runs total don't really take a dramatic jump in most ballparks save Texas and Milwaukee so some of his success may translate to other ballparks.
His quality of competition wasn't great as you've mentioned, a look at his game log shows a lot of outings against the likes of the Royals, Twins, Athletics, Rangers etc. and not much in the way of higher quality opposition so it's natural to wonder how he would fare against tougher quality of opposition. Some of that concern could be mitigated due to the more balanced schedule MLB is finally implementing, so he wouldn't regularly be facing the juggernaut opponents in the AL East.