Mostly every pitcher is at more of a disadvantage third time through the order, versus first or second. Though that doesn't mean some of your top starters can't pitch a third time through the order. Again a lot depends on score, matchups, game situation, pitch count, # of stressful innings/pitches prior and most importantly the bullpen arms you have available. No reason why some of the Blue Jays top starters like Manoah, Gausman and Berrios can't pitch past the seventh inning on occasion when they have a good pitch count and aren't laboring. If they're cruising along, keep them in.
If the score is 4-1 or 5-1 entering the 7th or 8th inning, and one of those starters is around 90 or so pitches, let them go out for the 7th or 8th and have guys in the BP warming up if need be. Again, depends on matchups at that time in the game.