After Alford stole 2nd they had about a 75% win expectancy.
The Espinal strikeout lowered it to 65.5%. Hard to say how much the bunt decision itself lowered run expectancy; Espinal might have whiffed even if swinging away.
After Fisher walked they had a 75% win expectancy again.
RE with 1st and 3rd one out is about 1.140
RE with 2nd and 3rd one out is about 1.352
Not only is the total RE higher with him on 2nd, the expectancy of getting one run is also probably higher as the double play is removed. So, if Fisher indeed has a 100% chance to get to 2nd they certainly have up a some odds of taking the lead.
Honestly, I think a really sharp manager pinch hits for Espinal in that inning. I think he had already K'd hopelessly against Scherzer twice. McGuire was the only one on the bench IIRC. It's awkward, sure, and most managers wouldn't do it, but you're really just taking about Drury at SS, Vlad at 3B, and Reese or Jansen at 1st, if they take the lead maybe just for one half inning. Espinal's naked projection is to hit .243/.288 while McGuire's is to hit .241/.300, but when you factor in handedness you're probably looking at like a .050 expected AVG/OBP split vs. Scherzer.