I don't think many teams could do very well without 3 of their top 6 hitters, but I've been wrong before. Not to mention Bautista playing banged up.
I don't know how any team could have the depth to not suffer after such injuries. Call it an excuse if you want, but take Cruz, Machado and another guy out of the O's line up and they won't have the depth. Same with the vaunted Red Sox, Yanks and Rays.
Anyway...