The 5th overall pick or your 5th round pick? A 5th round pick has virtually no value, but the 5th overall pick could be a nice trade chip. I traded my 1st rounder (#10) with Gay Sanchez and Jake Odoriffic for Ryan Zimmerman last year. In FC, I traded my 1st (#4 I think) with Christian Yelich and Syndergaard for Cargo. A 1st rounder certainly won't fetch you an all-star in their prime, but combined with another Top 25-50 prospect, you can definitely get a nice player.
Personally, I'm all about selling minor league assets to rebuilding teams for mid-prime 1st division players. I would advise you to wait until a few teams start falling back from the pack, then come in strong with a good MiLB package for players they might consider selling.