Even if they were the next Gore or Pearson, I still wouldn't do it. First, like you said, the injury risk. Second, the change in usage patterns (last year only 15 pitchers threw 200 innings or more) has drastically reduced the value of a SP.
With your top draft picks, you're hoping to get a 'franchise cornerstone,' someone who's going to be the star of your team, and starting pitchers just don't fill that role anymore. The jobs of Starter and Reliever are blending together at this point. The fact that only 3 HS pitchers were selected in the first round last year—the fewest since 2008—is a real trend going forward.