The run was unfortunate, but there were other mistakes on that play too. There was no chance of getting the runner at the plate. The throw should have come in to SS or 3B and kept the runner at 2nd. As for Little, he's actually been somewhat decent since coming back up. The walks are still WAY too high, although a few of those have been intentional.
We don't have many guys available today. Is Sewald or Waldron against lefties a better option? I kind of don't think so.