Small sample size but one slightly concerning thing is Berrios' record against the Red Sox, Yankees and Rays.
4.93 ERA vs Boston (34.2 IP)
5.79 ERA vs Yankees (14.0 IP)
7.15 ERA vs Rays (22.2 IP)
Not sure how many of those innings are from before he became really good but some teams just have better scouting reports on specific pitchers and if those AL East teams know something about getting to Berrios, it could be problematic for the Jays.
Ironically, the team he's dominated the hardest in his career is the Blue Jays.
0.46 ERA in 19.2 career innings against the Jays.