Well if we want to get dark here, how about the loss of life for an entire team (airplane crash?)
They would have to enact the Disaster draft
https://en.wikipedia.org/wiki/Disaster_draft
"If the commissioner decides that the disabled club will continue to play, the commissioner may hold a Restocking Draft to allow the disabled club to select as many players as it lost, with the restriction that no more than one player can be selected from each team. Each of the non-disabled teams makes five players available for the draft taken from its active list (or if during the off-season, from its reserve list), composed of one pitcher, one catcher, one outfielder, one infielder, and one more player of any position, subject to adjustments by the commissioner based on the players lost by the disabled club"