JS himself said he used Little to give the M's a "different look". In other words, if Hoffman or Seranthony had not pitched in a very low leverage situation in Game 4, one of them would have been used other than Little in Game 5, and the Jays have a better chance of winning.
Unless you have Little higher on your depth chart, for some reason.
FWIW, Roster Resource has Hoffman and Seranthony #1 and #2 on its bullpen depth chart, Little is #5.